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Kwizigulane ezine-mild dilated cardiomyopathy (MDCM), ugxininiso oluphakanyisiweyo lweprotheyini ye-C-reactive (hs-CRP) ehambelana nokunyuka kwamanqanaba e-N-terminal brain natriuretic peptide (NT-proBNP) kwizigulane ezine-mild dilated cardiomyopathy (MDCM) .), nangona kungekho bungqina bokuxhasa umphumo oqikelelwayo ohambelana neziphumo zesigulane.Iziphumo zapapashwa kwi-ESC Heart Failure jenali.
Uhlalutyo oluhlaziyiweyo lwezigulane ezine-cardiomyopathy (DCM) kunye neqhezu le-ventricular ejection elishiya ngaphantsi kwe-50% engeniswe kwisibhedlele saseFuwai eBeijing, eChina ukususela ngoDisemba 2006 ukuya ku-Oktobha 2017.Abaphandi bafuna ukuthelekisa i-biomarkers NT-proBNP kunye ne-hs-CRP kwizigulane ze-MDCM kunye nezigulane ze-DCM.Kulo cwaningo, i-MDCM yachazwa njengesalathisi se-ventricular end-diastolic diameter index (LVEDDi) ye-33 mm / m2 okanye ngaphantsi kwamadoda kunye ne-34 mm / m2 kubasetyhini.
Bebonke ngabathathi-nxaxheba abangama-640 babandakanyiwe kuhlalutyo, i-17% yabo yachazwa njengene-MDCM yaza i-83% yachazwa njengene-DCM ekuqaleni.Lilonke, ama-24.8% abathathi-nxaxheba ibingabasetyhini.Ubudala obuqhelekileyo bezigulane yiminyaka engama-49.
Xa kuthelekiswa nabathathi-nxaxheba be-DCM, izigulane ze-MDCM zazincinci, zinexinzelelo oluphezulu lwegazi, iziganeko eziphezulu zesifo sikashukela, izinga eliphantsi le-tachycardia ye-ventricular engapheliyo, isalathisi esiphezulu somzimba, kunye nokuhlala esibhedlele esifutshane. Ngokumalunga ne-biomarkers ye-cardiac, izigulane ezine-MDCM zinezinga eliphantsi kakhulu le-NT-proBNP ephakathi xa kuthelekiswa nezigulane ezine-DCM (2203 pg / mL vs 1448 pg / mL, ngokulandelanayo; P <.001). Ngokumalunga ne-biomarkers, izigulane ezine-MDCM zinezinga eliphantsi kakhulu le-NT-proBNP xa kuthelekiswa nezigulane ezine-cardiac DCM (2203 pg / mL vs 1448 pg / mL, ngokulandelanayo; P <.001). Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнениентов с пацие 4/20 DC; Ngokumalunga ne-biomarkers ye-cardiac, izigulane ze-MDCM zinezinga eliphantsi kakhulu le-NT-proBNP xa kuthelekiswa nezigulane ze-DCM (2203 pg / mL vs. 1448 pg / mL, ngokulandelanayo; P <0.001).关于心脏生物标志物，与DCM 患者相比，MDCM 患者的NT-proBNP 水平中位数显着降低和（分20别4 pm/Pm1.I-MDCM 患者的NT-proBNP 水平中位数显着降低（分别，与2203 pg/mL 和L0.0 pg/mL 和L0.0 Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнежение, 10, 10, 10, 1, 1, 1, 1, 1, 1, 20 Ngokumalunga ne-biomarkers ye-cardiac, amanqanaba e-NT-proBNP aphantsi kakhulu kwizigulane ze-MDCM xa kuthelekiswa nezigulane ze-DCM (2203 pg / mL kunye ne-1448 pg / mL, ngokulandelanayo; P <0.001).Ngokwahlukileyo, amanqanaba e-hs-CRP athetha ukuba aphezulu kwizigulane ze-MDCM kunezigulane ze-DCM (3.09 mg / L kunye ne-2.79 mg / L, ngokulandelanayo; P = 0.39).
Phakathi kwezigulane ze-282 eziye zafumana ukulandelwa kwe-echocardiographic ngexesha leenyanga ze-6 okanye ngaphezulu, izigulane ze-7 ezine-MDCM (11.1%) ziphuhlise i-DCM, ngelixa izigulane ze-70 ezine-DCM (32.0%) zibuyele kwi-MDCM, njengoko utshintsho kwi-LVEDDi lwabonwa.
Isiseko sezigulane ze-MDCM zazinomngcipheko ophantsi odibeneyo wokufa konke, ukutshintshwa kwentliziyo, kunye nokufundwa kwentliziyo ngenxa yokungaphumeleli kwentliziyo xa kuthelekiswa nabathathi-nxaxheba be-DCM (i-hazard ratio elungisiweyo [aHR], 0.63; 95% CI, 0.43-0.93; P = 0.019).
Zombini i-hs-CRP kunye ne-NT-proBNP amanqanaba adityaniswa ngokuzimeleyo kunye nesiphelo esidibeneyo kulo lonke iqela lokufunda (hs-CRP, aHR, 1.07; 95% CI, 1.00-1.15 kunye ne-NT-proBNP: aHR, 1.11, 95% CI, 1.02–1.22, p = 0.019).
Emva kokuthelekisa amanqaku e-propensity phakathi kwe-MDCM kunye ne-DCM, umbutho phakathi kwamanqanaba aphezulu e-NT-proBNP kunye nesiphelo esidibeneyo sasihambelana nengxelo ngaphambi kokuthelekisa izigulane ezine-DCM (RR, 1.83; 95% CI, 1.05-3.20; P = 0.034), kodwa kungekhona kwizigulane ezine-MDCM (HR, 1.54, 95% CI, 0.76-3.11, P = 0.227).Ngokwahlukileyo, amanqanaba e-hs-CRP ayesadibaniswa kakhulu ne-prognosis kwizigulane ezine-MDCM (RR 3.19; 95% CI 1.52-6.66; P = 0.002), kodwa kungekhona kwizigulane ezine-DCM (RR 1.04; 95% CI).0.61–1,79;p = 0.88).
Umda wophononongo kukuba i-phenotype yezigulane inokutshintsha ngexesha lokulandelwa, nangona inani labantu abaye baphinda baphinda be-echocardiography lalincinci kakhulu, ngoko ke i-predictors yenguqu ye-phenotypic ayizange ihlalutywe.Ukongezelela, ngenxa yesayizi encinci yesampula yezigulane ze-MDCM kwisifundo, izinto ezinokuthi ziphazamiseke azizange zilungelelaniswe ngokupheleleyo kwi-multivariate analysis.
"Isiseko se-hs-CRP sidibene neziphumo ezidibeneyo kwizigulane ze-MDCM ngaphambi nangemva kokulungiswa kwee-covariates, ngelixa i-NT-proBNP yayinxulumene kuphela neziphumo kwi-DCM," ababhali bokufunda bathi."Uphononongo olongezelelweyo lufunekayo ukuphanda ukubikezelwa kweenguqu kwijometri ye-ventricular kunye nomsebenzi wenhliziyo, ngakumbi kwizigulane ezine-MDCM, ukubonelela ngokuchaneka komngcipheko."
Isibhengezo: Akukho namnye kubabhali bophononongo owabanga ukuzibandakanya ne-biotech, amayeza, kunye/okanye iinkampani zesixhobo.
Feng J, Tian P, Liang L, et al.Isiphumo kunye nexabiso le-prognostic ye-N-terminal pro-brain natriuretic peptide kunye ne-high-sensitivity C-reactive protein kwi-cardiomyopathies ethambileyo kunye neyongeziweyo.Ukungaphumeleli kwentliziyo kweESC.Ipapashwe kwi-intanethi ngoMatshi 4, 2022 doi: 10.1002/ehf2.13864
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