Iimveliso

I-Immunoassay yokuzimisela kobungakanani be-in vitro yoxinaniso lwe-D-Dimer kwi-serum yabantu kunye neplasma.Kungabandakanyi i-pulmonary embolism kangangemizuzu eli-15 kwindawo ekufutshane nesigulane.

I-D-dimer yi-fibrin polymer yamaqhekeza e-DD e-cross-linked fibrin molekyuli ezenziwe phantsi kwe-enzymolysis ye-plasmin.Ibhalansi eguquguqukayo phakathi kweplasmin kunye ne-enzyme ye-inhibitory igcinwa kubantu abanamandla ukuze ukujikeleza kwegazi kuqhutywe ngokuqhelekileyo.Inkqubo ye-fibrinolytic emzimbeni womntu idlala indima ebalulekileyo ekugcineni ukunyanzeliswa okuqhelekileyo kodonga lwegazi kunye nokuhamba kwegazi kunye nokulungiswa kwezicubu.Ukugcina isimo esiqhelekileyo somzimba, kwimeko yokulimala okanye umonakalo we-vascular , ukubunjwa kwe-thrombus kunokuthintela ukulahleka kwegazi kwimizila yegazi eyonakalisiweyo.Ngaphantsi kweemeko ze-pathological, xa i-coagulation isenzeka emzimbeni, i-thrombin isebenza kwi-fibrin, kwaye inkqubo ye-fibrinolytic ivuliwe ukuze ithobe i-fibrin kwaye yenze iziqwenga ezahlukeneyo.Ikhonkco le-R linokudibanisa amaqhekeza amabini aqulethe i-D fragment ukwenza i-D-dimer.Ukunyuka kwenqanaba le-D-dimer kubonisa ukubunjwa kwegazi kwi-vascular circulatory system.Luphawu olubuthathaka lwe-acute thrombosis, kodwa aluthanga ngqo.